Most obese people don't achieve sustained weight loss from diet, so in most instances it's not useful to compare GLP-1 weight loss with weight loss from behavioral interventions. Weight loss in those with obesity achieved outside of an illness generally improves health. Some of the GLP -1 benefits precede weight loss so there might be some anti inflammatory effects of GLP-1 drugs, too.
From Patricia:
Certainly the weight loss itself is a compelling cause of these benefits, but we may find later that there are direct effects of tirzepatide or other GLP-1 medications. Below is a link to a Cell Metabolism article reporting that GLP-1 receptors are found throughout the body and have impacts on inflammation and other processes that we don’t yet understand. https://tinyurl.com/e83z79v9
Pat and Jeff-
How do you think about differentiating the benefits of weight loss in general from weight loss from GLP agonists?
From Jeff:
Most obese people don't achieve sustained weight loss from diet, so in most instances it's not useful to compare GLP-1 weight loss with weight loss from behavioral interventions. Weight loss in those with obesity achieved outside of an illness generally improves health. Some of the GLP -1 benefits precede weight loss so there might be some anti inflammatory effects of GLP-1 drugs, too.
From Patricia:
Certainly the weight loss itself is a compelling cause of these benefits, but we may find later that there are direct effects of tirzepatide or other GLP-1 medications. Below is a link to a Cell Metabolism article reporting that GLP-1 receptors are found throughout the body and have impacts on inflammation and other processes that we don’t yet understand. https://tinyurl.com/e83z79v9